A subset of natural killer cells in peripheral blood displays a mature T cell phenotype

@article{Schmidt1986ASO,
  title={A subset of natural killer cells in peripheral blood displays a mature T cell phenotype},
  author={Reinhold Ernst Schmidt and Clifford Murray and John F. Daley and Stuart F. Schlossman and Jerome Ritz},
  journal={The Journal of Experimental Medicine},
  year={1986},
  volume={164},
  pages={351 - 356}
}
Normal human PBMC were analyzed for the presence of cells expressing both T3 and NKH1 antigens, using direct two-color immunofluorescence. In six individuals, NKH1+T3+ cells were found to represent 2.5% of PBMC and 24% of the total number of NKH1+ cells. Purified NKH1+T3+ cells were shown to have the typical morphology of large granular lymphocytes (LGL). NKH1+T3+ cells also exhibited spontaneous cytotoxicity against K562 target cells and this lytic activity could be inhibited by anti-T3 mAb… CONTINUE READING