A subset of dendritic cells induces CD4+ T cells to produce IFN-γ by an IL-12–independent but CD70-dependent mechanism in vivo

@article{Soares2007ASO,
  title={A subset of dendritic cells induces CD4+ T cells to produce IFN-γ by an IL-12–independent but CD70-dependent mechanism in vivo},
  author={Helena Soares and Haena Waechter and Nicholas Glaichenhaus and Evelyne Mougneau and H. Yagita and Olga A Mizenina and Diana Dudziak and Michel C. Nussenzweig and Ralph Marvin Steinman},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={1095 - 1106}
}
Interferon (IFN)-gamma, a cytokine critical for resistance to infection and tumors, is produced by CD4(+) helper T lymphocytes after stimulation by cultured dendritic cells (DCs) that secrete a cofactor, interleukin (IL)-12. We have identified a major IL-12-independent pathway whereby DCs induce IFN-gamma-secreting T helper (Th)1 CD4(+) T cells in vivo. This pathway requires the membrane-associated tumor necrosis family member CD70 and was identified by targeting the LACK antigen from… CONTINUE READING
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