A subset of cytolytic dendritic cells in rat.

  title={A subset of cytolytic dendritic cells in rat.},
  author={Benjamin Trinit{\'e} and C{\'e}cile Voisine and H. Yagita and R{\'e}gis Josien},
  journal={Journal of immunology},
  volume={165 8},
Dendritic cells (DCs) are a rare population of leukocytes specialized in Ag processing and presentation to T cells. We have previously shown that cultured rat splenic DCs exhibit a cytotoxic activity against selected target cells. In this study, we analyzed this function in DCs freshly prepared from lymphoid organs using the DC-specific OX62 mAb and magnetic beads. Freshly extracted splenic DCs, but not lymph node and thymic DCs, exhibited a strong and moderate cytotoxic activity against YAC-1… CONTINUE READING