A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation

@inproceedings{Rijkers2018ASO,
  title={A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation},
  author={Maaike Rijkers and Anno Saris and Sebastiaan Heidt and Arend Mulder and Leendert Porcelijn and Frans H J Claas and Ruben Bierings and Frank W. G. Leebeek and A. J. Gerard Jansen and Gestur Vidarsson and Jan Voorberg and Masja de Haas},
  booktitle={Haematologica},
  year={2018}
}
HLA antibodies are associated with refractoriness to platelet transfusion, leading to rapid platelet clearance, sometimes coinciding with clinical side effects such as fever and chills. The presence of HLA antibodies is not always manifested by clinical symptoms. It is currently unclear why refractoriness to platelet transfusion is only observed in a subset of patients. Here, we utilized the availability of a unique panel of human monoclonal antibodies to study whether these were capable of… CONTINUE READING
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