A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap.

@article{Cao2010ASM,
  title={A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap.},
  author={Jingtai Cao and Lian Zhao and Yiwen Li and Yang Liu and Weihong Xiao and Ying Song and Lingyu Luo and Deqiang Huang and George D. Yancopoulos and Stanley J. Wiegand and Rong Wen},
  journal={Investigative ophthalmology & visual science},
  year={2010},
  volume={51 11},
  pages={6009-17}
}
PURPOSE The exudative, or the wet form of age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV). A subretinal Matrigel (BD Biosciences, Bedford MA) model of CNV is described here, along with the effects of vascular endothelial growth factor (VEGF) neutralization on the development of CNV and associated inflammation and fibrosis. METHODS CNV was induced in adult Sprague-Dawley rats by subretinal injection of Matrigel. CNV growth and associated leukocyte… CONTINUE READING

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