A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature.

@article{Cooley2007ASO,
  title={A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature.},
  author={Sarah Cooley and Feng Xiao and Michelle Pitt and Michelle H Gleason and Valarie McCullar and Tracy L. Bergemann and Karina L. McQueen and Lisbeth A. Guethlein and Peter Parham and Jeffrey S Miller},
  journal={Blood},
  year={2007},
  volume={110 2},
  pages={578-86}
}
How receptor acquisition correlates with the functional maturation of natural killer (NK) cells is poorly understood. We used quantitative real-time polymerase chain reaction (PCR) assays to compare NKG2 and killer immunoglobulin-like receptor (KIR) gene expression in NK cells from allogeneic transplant recipients and their donors. Marked differences were observed in the NK subsets of recipients who had 8-fold more CD56(bright) cells, diminished KIR expression (except 2DL4), and increased NKG2A… CONTINUE READING
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