A subpopulation of dopamine D1 receptors mediate repetitive jaw movements in rats.


Repetitive jaw movements (RJM) in rats, a potentially useful animal model of tardive dyskinesia, appears to be mediated by the dopamine D1 receptor as evidenced in part by their induction and inhibition with D1 agonists and D1 antagonists, respectively. Selective destruction of 60-90% of D1 receptors by EEDQ, measured in several CNS dopaminergically… (More)