A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

@article{HayashiNishino2009ASO,
  title={A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation},
  author={Mitsuko Hayashi-Nishino and Naonobu Fujita and Takeshi Noda and Akihito Yamaguchi and Tamotsu Yoshimori and Akitsugu Yamamoto},
  journal={Nature Cell Biology},
  year={2009},
  volume={11},
  pages={1433-1437}
}
Autophagy is a bulk degradation process in eukaryotic cells and has fundamental roles in cellular homeostasis.The origin and source of autophagosomal membranes are long-standing questions in the field. Using electron microscopy, we show that, in mammalian culture cells, the endoplasmic reticulum (ER) associates with early autophagic structures called isolation membranes (IMs). Overexpression of an Atg4B mutant, which causes defects in autophagosome formation, induces the accumulation of ER–IM… CONTINUE READING
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