A subcellular map of the human proteome

@article{Thul2017ASM,
  title={A subcellular map of the human proteome},
  author={Peter J. Thul and Lovisa {\AA}kesson and Mikaela Wiking and Diana Mahdessian and Aikaterini Geladaki and Hammou Ait Blal and T. Alm and A. Asplund and L. Bj{\"o}rk and L. M. Breckels and Anna B{\"a}ckstr{\"o}m and F. Danielsson and L. Fagerberg and J. Fall and L. Gatto and Christian Gnann and S. Hober and Martin Hjelmare and Fredric Johansson and Sunjae Lee and C. Lindskog and J. Mulder and Claire M. Mulvey and P. Nilsson and P. Oksvold and J. Rockberg and Rutger Schutten and J. Schwenk and {\AA}sa Sivertsson and E. Sj{\"o}stedt and Marie Skogs and Charlotte Stadler and Devin P. Sullivan and H. Tegel and Casper F. Winsnes and Cheng Zhang and Martin Zwahlen and A. Mardinoglu and F. Pont{\'e}n and Kalle von Feilitzen and K. Lilley and M. Uhl{\'e}n and E. Lundberg},
  journal={Science},
  year={2017},
  volume={356}
}
  • Peter J. Thul, Lovisa Åkesson, +40 authors E. Lundberg
  • Published 2017
  • Medicine, Biology
  • Science
  • Mapping the proteome Proteins function in the context of their environment, so an understanding of cellular processes requires a knowledge of protein localization. Thul et al. used immunofluorescence microscopy to map 12,003 human proteins at a single-cell level into 30 cellular compartments and substructures (see the Perspective by Horwitz and Johnson). They validated their results by mass spectroscopy and used them to model and refine protein-protein interaction networks. The cellular… CONTINUE READING

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