A subcellular map of the human proteome

  title={A subcellular map of the human proteome},
  author={Peter J. Thul and Lovisa {\AA}kesson and Mikaela Wiking and Diana Mahdessian and Aikaterini Geladaki and Hammou Ait Blal and Tove Alm and Anna Asplund and Lars Bj{\"o}rk and Lisa M. Breckels and Anna B{\"a}ckstr{\"o}m and Frida Danielsson and Linn Fagerberg and Jenny Fall and Laurent Gatto and Christian Gnann and Sophia Hober and Martin Hjelmare and Fredric Johansson and Sunjae Lee and Cecilia Lindskog and Jan Mulder and Claire M. Mulvey and Peter Nilsson and Per Oksvold and Johan Rockberg and Rutger Schutten and Jochen M. Schwenk and {\AA}sa Sivertsson and Evelina Sj{\"o}stedt and Marie Skogs and Charlotte Stadler and Devin P. Sullivan and Hanna Tegel and Casper F. Winsnes and Cheng Zhang and Martin Zwahlen and Adil Mardinoğlu and Fredrik Pont{\'e}n and Kalle von Feilitzen and Kathryn S. Lilley and Mathias Uhl{\'e}n and Emma Lundberg},
Mapping the proteome Proteins function in the context of their environment, so an understanding of cellular processes requires a knowledge of protein localization. Thul et al. used immunofluorescence microscopy to map 12,003 human proteins at a single-cell level into 30 cellular compartments and substructures (see the Perspective by Horwitz and Johnson). They validated their results by mass spectroscopy and used them to model and refine protein-protein interaction networks. The cellular… 

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