A study using irreversible electroporation to treat large, irregular tumors in a canine patient

@article{Neal2010ASU,
  title={A study using irreversible electroporation to treat large, irregular tumors in a canine patient},
  author={Robert E. Neal and Paulo A. Garcia and John H. Rossmeisl and Rafael V. Davalos},
  journal={2010 Annual International Conference of the IEEE Engineering in Medicine and Biology},
  year={2010},
  pages={2747-2750}
}
  • R. E. Neal, P. A. Garcia, +1 author R. Davalos
  • Published 11 November 2010
  • Medicine
  • 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology
Irreversible electroporation (IRE) has shown promise for the therapeutic treatment of focal disease, including tumors. The effects of treatment are dependent on the electric field distribution, which may be predicted with numerical modeling. In order to improve the effectiveness and scope of IRE therapies, techniques must be developed for designing protocols capable of treating large and irregular tumors. We present the findings of a study designing an IRE treatment plan for a canine patient… 
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References

SHOWING 1-10 OF 16 REFERENCES
Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode
TLDR
Tumor regression was observed in 5 out of 7 MDA-MB231 human mammary tumors orthotopically implanted in female Nu/Nu mice, with continued growth in controls.
Tissue Ablation with Irreversible Electroporation
TLDR
It is shown through mathematical analysis that irreversible electroporation can ablate substantial volumes of tissue, comparable to those achieved with other ablation techniques, without causing any detrimental thermal effects and without the need of adjuvant drugs.
Tumor Ablation with Irreversible Electroporation
TLDR
The first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice was reported, and induced complete regression in 12 out of 13 treated tumors, in the absence of tissue heating.
The Feasibility of Irreversible Electroporation for the Treatment of Breast Cancer and Other Heterogeneous Systems
TLDR
Investigating applying IRE to treat primary breast tumors located within a fatty extracellular matrix despite IREs dependence on the heterogeneous properties of tissue found treatment-relevant protocols were found to be capable of treating targeted tissue over a large range of heterogeneity properties without inducing significant thermal damage.
Imaging Guided Percutaneous Irreversible Electroporation: Ultrasound and Immunohistological Correlation
TLDR
Percutaneous irreversible electroporation can provide a novel and unique ablative method with real-time monitoring capability, ultra-short procedure time, non-thermal ablation, and well-controlled and focused apoptotic cell death.
In vivo results of a new focal tissue ablation technique: irreversible electroporation
TLDR
Results of in vivo experiments that confirm the feasibility of a new minimally invasive method for tissue ablation, irreversible electroporation (IRE), and demonstrates that IRE can become an effective method for nonthermal tissueAblation requiring no drugs.
A Study of the Immunological Response to Tumor Ablation with Irreversible Electroporation
TLDR
It is proposed that irreversible electroporation may be a treatment modality of interest to immunodepressed cancer patients because of its potential for boosting immune response to treat sarcoma tumors.
Irreversible Electroporation: Implications for Prostate Ablation
TLDR
Ireversible electroporation IRE lesions in the prostate had unique characteristics compared to thermal lesions, and the differences could be very advantageous in a clinical setting, improving the results and acceptance of prostate ablation.
The Effect of Irreversible Electroporation on Blood Vessels
TLDR
It is tentatively suggested that IRE has possible applications to treatment of pathological processes in which it is desired to reduce the proliferation of VSMC population, such as restenosis and for attenuating atherosclerotic processes in clinical important locations such as coronary, carotid and renal arteries.
The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals
TLDR
The results and the reversible and irreversible thresholds used coincide well with the effectiveness of the electrochemotherapy in real tumors where experiments show antitumor effectiveness for amplitudes higher than 900 V/cm ratio and pronounced antitumors effects at 1300 V/ cm ratio.
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