• Corpus ID: 46910917

A study on the role of genes of innate immunity in type 1 diabetes

@inproceedings{Sedimbi2010ASO,
  title={A study on the role of genes of innate immunity in type 1 diabetes},
  author={Saikiran K. Sedimbi},
  year={2010}
}
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic β-cells. It is a polygenic disease in which maximal genetic susceptibility is conferred by the presence of MHC class II genes. Circulating autoantibodies against islet cell antigens and mononuclear cell infiltrates, especially CD4 + and CD8 + T cells, are characteristic of the disease. Recent evidence suggests innate immunity may be involved in the disease pathogenesis. The aim of this thesis is to… 

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