Corpus ID: 104738809

A study on the possible role of mitochondrial damage reactive nitrogen species and reactive oxygen species in the pathogenesis of methotrexate induced small intestinal damage in the rat

@inproceedings{Kolli2011ASO,
  title={A study on the possible role of mitochondrial damage reactive nitrogen species and reactive oxygen species in the pathogenesis of methotrexate induced small intestinal damage in the rat},
  author={Viswa Kalyan Kolli},
  year={2011}
}
  • Viswa Kalyan Kolli
  • Published 2011
  • Chemistry
  • Methotrexate is widely used in the treatment of different malignancies and inflammatory disorders. The therapeutic effect of the drug is through the competitive inhibition of dihydrofolate reductase (DHFR), thus blocks the de novo nucleotide synthesis primarily by depleting cells of reduced tetrahydrofolate cofactors resulting in decreased availability of folate required for DNA synthesis and cell proliferation. However, the use of the drug is often associated with significant adverse… CONTINUE READING

    References

    SHOWING 1-10 OF 571 REFERENCES
    Protective effect of lipoic acid against methotrexate-induced oxidative stress in liver mitochondria.
    • 78
    Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats
    • 130
    Methotrexate: pentose cycle and oxidative stress
    • 160