A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells

@inproceedings{Zhou2015ASO,
  title={A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells},
  author={Yanfang Zhou and Jiemei Li and Fang Lu and Junjie Deng and Jiahua Zhang and Peijie Fang and Xinsheng Peng and Shu-Feng Zhou},
  booktitle={Drug design, development and therapy},
  year={2015}
}
Dendrimers are hyperbranched macromolecules with well-defined topological structures and multivalent functionalization sites, but they may cause cytotoxicity due to the presence of cationic charge. Recently, we have introduced alkyne-terminated poly(amidoamine) (PAMAM) dendrons of different generations (G=2,3) into chitosan to obtain dendronized chitosan derivatives [Cs-g-PAMAM (G=2,3)], which exhibited a better water solubility and enhanced plasmid DNA transfection efficiency. In this study… CONTINUE READING
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