A study on the antitumoral and differentiation effects of peganum harmala derivatives in combination with ATRA on leukaemic cells.

@article{Zaker2007ASO,
  title={A study on the antitumoral and differentiation effects of peganum harmala derivatives in combination with ATRA on leukaemic cells.},
  author={Farhad Zaker and Arezo Oody and Alireza Arjmand},
  journal={Archives of pharmacal research},
  year={2007},
  volume={30 7},
  pages={844-9}
}
Plant derived agents may exert a new approach to the treatment of leukaemia. The present study was an evaluation of proliferation, cytotoxicity and differentiation of harmine and harmaline on HL60 cells, alone or in combination with ATRA and G-CSF. Counting of cells, viability, MTT assay, morphology, NBT reduction and flow cytometry analysis were performed using CD11b and CD 14 monoclonal antibodies. The data showed that harmine and harmaline reduced proliferation in dose and time dependent… CONTINUE READING
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