A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats.

@article{Rai2013ASO,
  title={A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats.},
  author={Shivika Rai and Pradeep Kumar Kamat and Chandishwar Nath and Rakesh Shukla},
  journal={Journal of neuroimmunology},
  year={2013},
  volume={254 1-2},
  pages={1-9}
}
Present study was designed to investigate the status of neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats. STZ produced significant increase in proinflammatory cytokines (TNF-α and IL-1β), ROS, nitrite and mRNA and protein expression of iNOS and nNOS indicating a state of neuroinflammation in rat brain which was significantly prevented by Memantine and Ibuprofen treatment. STZ also significantly altered NMDA subunits, NR2A and NR2B protein and mRNA… CONTINUE READING

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