A study of the vascular and acid-secretory responses of the rat gastric mucosa to histamine.

@article{Main1976ASO,
  title={A study of the vascular and acid-secretory responses of the rat gastric mucosa to histamine.},
  author={Ian Main and Brendan J. R. Whittle},
  journal={The Journal of physiology},
  year={1976},
  volume={257 2},
  pages={407-18}
}
1. The effects of histamine on gastric mucosal blood flow in the presence and absence of gastric acid secretion were studied in the rat. 2. Histamine, in doses greater than those required to stimulate maximal acid secretion, caused a small increase in mucosal blood flow per unit acid output. 3. When acid secretion was inhibited by methyl analogues of prostaglandin E2, histamine reduced arterial blood pressure and gave a dose dependent rise in mucosal blood flow. 4. When acid secretion was… CONTINUE READING