A study of the possible influence of central 5-HT function on clonidine-induced hypoactivity responses in mice

@article{Heal1987ASO,
  title={A study of the possible influence of central 5-HT function on clonidine-induced hypoactivity responses in mice},
  author={David J. Heal and J W Philpot},
  journal={Psychopharmacology},
  year={1987},
  volume={92},
  pages={219-223}
}
Administration of the α2-adrenoceptor agonist clonidine (0.1 mg/kg) produces hypoactivity in mice. This sedation response was unaltered by pretreatment with either the 5-HT reuptake inhibitor zimeldine (1 or 10 mg/kg) or the 5-HT agonist quipazine (0.25 or 2.5 mg/kg). The 5-HT1B agonist RU 24969 (0.2 or 1 mg/kg) enhanced hypoactivity responses at the higher dose. The non-selective 5-HT antagonists methysergide (1 or 10 mg/kg) and metergoline (0.2 or 1 mg/kg) potentiated clonidine-induced… CONTINUE READING