A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging

@article{Ciccarelli2003ASO,
  title={A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging},
  author={Olga Ciccarelli and David J Werring and Gareth J. Barker and Colette M B Griffin and Claudia A. M. Wheeler-Kingshott and David H. Miller and Alan J. Thompson},
  journal={Journal of Neurology},
  year={2003},
  volume={250},
  pages={287-292}
}
Diffusion tensor imaging (DTI) investigates brain tissue microstructure in vivo. In multiple sclerosis (MS) Wallerian degeneration of axons traversing focal lesions is a potential mechanism of damage in normal-appearing white matter. In vivo evidence for this hypothesis is limited. The present study investigated the relationship between DTI-derived indices in the normal-appearing corpus callosum (CC) and the lesion loads (LLs) in connected cerebral regions. DTI was performed in 39 MS patients… CONTINUE READING