A study of the mechanism of resistance to Adriamycin in vivo. Glutathione metabolism, P-glycoprotein expression, and drug transport.

@article{Lee1989ASO,
  title={A study of the mechanism of resistance to Adriamycin in vivo. Glutathione metabolism, P-glycoprotein expression, and drug transport.},
  author={Francis Y. Lee and J J Sciandra and Dietmar W. Siemann},
  journal={Biochemical pharmacology},
  year={1989},
  volume={38 21},
  pages={3697-705}
}
A spontaneously originated murine mammary adenocarcinoma (16C), selected for its sensitivity to agents active against breast cancer in women, and one of the very few experimental solid tumor models responsive to Adriamycin (ADR) was used to study the mechanism of induced ADR resistance in vivo. A resistant variant of the tumor was obtained from the explant… CONTINUE READING