A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver.

@article{Sivapathasundaram2001ASO,
  title={A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver.},
  author={Susila Sivapathasundaram and Paraskevi Magnisali and Nick G. Coldham and Laurence C Howells and Maurice J. Sauer and Costas Ioannides},
  journal={Biochemical pharmacology},
  year={2001},
  volume={62 5},
  pages={635-45}
}
The expression of xenobiotic-metabolising cytochrome P450 proteins in the liver of cattle was determined using substrate probes and immunologically by Western blot analysis. Compared to the rat, cattle displayed much higher coumarin 7-hydroxylase (CYP2A) and ethoxyresorufin O-deethylase (CYP1) activity but, in contrast, it exhibited much lower debrisoquine 4-hydroxylase (CYP2D) and lauric acid hydroxylase activities (CYP4A). The ethoxyresorufin O-deethylase activity was markedly inhibited by… CONTINUE READING

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