A study of the effects of nicotine in the intact dog and the propensity for arrhythmias.


This is a study of the effects of nicotine exposure in the intact dog on the propensity for arrhythmias. The mean effective and total refractory periods were prolonged after nicotine. The diastolic current threshold was increased after nicotine in every animal, yet the threshold for repetitive firing was decreased in four animals, all of which had… (More)