• Corpus ID: 68468645

A study of the delayed type hypersensitivity response to varicella zoster virus antigen to investigate defects in cutaneous immunity in the elderly

@inproceedings{Sandhu2014ASO,
  title={A study of the delayed type hypersensitivity response to varicella zoster virus antigen to investigate defects in cutaneous immunity in the elderly},
  author={Daisy Sandhu},
  year={2014}
}
  • D. Sandhu
  • Published 28 April 2014
  • Medicine, Biology
Immunity declines with ageing resulting in an increase in incidence and severity of infections such as shingles. We used the delayed type hypersensitivity response as a model for a memory T cell response to investigate differences in the response to VZV antigen administered into the skin between old and young individuals. We found that there is a reduced clinical response, which is associated with a lack of T cell accumulation in the old subjects. The earliest differences between the two groups…