A study of the biological partitioning behavior of n-alkanes and n-alkanols in causing anesthetic effects.

@article{Hau2002ASO,
  title={A study of the biological partitioning behavior of n-alkanes and n-alkanols in causing anesthetic effects.},
  author={K M Hau and David W Connell and Bruce J. Richardson},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2002},
  volume={35 2 Pt 1},
  pages={273-9}
}
n-Alkanes and n-alkanols are two groups of common volatile organic compounds (VOCs) having potential anesthetic effects on workers and building occupants. A partition model based on the octanol-air partition coefficient was developed in this investigation to describe the biological partitioning of n-alkanes and n-alkanols in causing general anesthesia. Data on anesthetic potency (minimum alveolar concentration, MAC) for the test groups in rats were found to fit the model. The slight difference… CONTINUE READING

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