A study of the YopD-lcrH interaction from Yersinia pseudotuberculosis reveals a role for hydrophobic residues within the amphipathic domain of YopD.

@article{Francis2000ASO,
  title={A study of the YopD-lcrH interaction from Yersinia pseudotuberculosis reveals a role for hydrophobic residues within the amphipathic domain of YopD.},
  author={Matthew S Francis and Margareta Aili and Maria Lennern{\"a}s Wiklund and Hans Wolf-Watz},
  journal={Molecular microbiology},
  year={2000},
  volume={38 1},
  pages={
          85-102
        }
}
The enteropathogen Yersinia pseudotuberculosis is a model system used to study the molecular mechanisms by which Gram-negative pathogens translocate effector proteins into target eukaryotic cells by a common type III secretion machine. Of the numerous proteins produced by Y. pseudotuberculosis that act in concert to establish an infection, YopD (Yersinia outer protein D) is a crucial component essential for yop regulation and Yop effector translocation. In this study, we describe the mechanisms… CONTINUE READING

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