A study of synaptic transmission in the absence of nerve impulses

@article{Katz1967ASO,
  title={A study of synaptic transmission in the absence of nerve impulses},
  author={Bernard Katz and Ricardo Miledi},
  journal={The Journal of Physiology},
  year={1967},
  volume={192}
}
  • B. Katz, R. Miledi
  • Published 1 September 1967
  • Chemistry, Medicine
  • The Journal of Physiology
1. The axo‐axonic giant synapse in the stellate ganglion of the squid has been used to study synaptic transmission. 
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The effect of calcium on synaptic transmission has been studied by intracellular recording of pre‐ and post‐synaptic potential changes in the stellate ganglion of the squid by using Na6(CO3)(SO4)2, Na2SO4, and Na2CO3 as slurs. Expand
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  • R. Miledi
  • Chemistry, Medicine
  • The Journal of physiology
  • 1972
TLDR
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TLDR
The electric properties of the giant synapse in the stellate ganglion of the squid have been further investigated and it is shown that the synapse has an electric property similar to that of a ‘spatially aggregating cell’. Expand
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TLDR
The action of Ca on membrane excitability and synaptic transmission at motoneurones of the isolated spinal cord of the frog has been studied and it is shown that Ca acts as a “spatially aggregating force” to drive motoneuron excitability. Expand
The effect of prolonged depolarization on synaptic transfer in the stellate ganglion of the squid
1. Depolarization of the giant axon terminal of the squid causes local calcium influx which gives rise to transmitter release and post‐synaptic response, and which under certain experimentalExpand
Voltage sensitive calcium channels in the presynaptic terminals of a decrementally conducting photoreceptor
1. Intracellular recordings were made from the presynaptic regions of the photoreceptors of the median ocellus of the giant barnacle, Balanus nubilus.
Miniature synaptic potentials at frog spinal neurones in the presence of tetrodotoxin
1. Spontaneous subthreshold potentials have been recorded with an intracellular electrode from neurones of the isolated spinal cord of the frog.
Transmitter release by mammalian motor nerve terminals in response to focal polarization
1. A method is described by which mammalian motor nerve terminals may be uniformly polarized by focally applied current, and the extra‐cellular potential in the synaptic cleft, corresponding to anyExpand
The role of calcium in neuromuscular facilitation
1. The hypothesis is put forward that a residue of the ‘active calcium’ which enters the terminal axon membrane during the nerve impulse is responsible for short‐term facilitation.
Modification of transmitter release by ions which prolong the presynaptic action potential
1. The action of ions which increase the nerve spike duration at Ranvier's node has been studied at the neuromuscular junction of the frog.
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References

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Spontaneous synaptic potentials and quantal release of transmitter in the stellate ganglion of the squid
  • R. Miledi
  • Chemistry, Medicine
  • The Journal of physiology
  • 1967
TLDR
Several kinds of synapses have been studied in the stellate ganglion of the squid, and the structure and function of these synapses are still under investigation. Expand
The action of calcium on neuronal synapses in the squid
TLDR
The isolated stellate ganglion of the squid was studied with intracellular and extracellular micro‐electrodes and 1‐3 small presynaptic spikes could be recorded from within the post‐synaptic axon. Expand
The timing of calcium action during neuromuscular transmission
TLDR
Brief depolarizing pulses applied to a motor nerve ending cause packets of acetylcholine to be released and evoke end‐plate potentials (e.p.s), provided calcium ions are present in the extracellular fluid. Expand
Miniature Synaptic Potentials in Squid Nerve Cells
TLDR
It now seems quite certain that the transmission of impulses across both types of synapses is effected by the release of a transmitter substance. Expand
A study on the mechanism of impulse transmission across the giant synapse of the squid
TLDR
An attempt is made to elucidate the mechanism of impulse transmission across this giant synapse of the squid by using various techniques. Expand
Changes in end‐plate activity produced by pre‐synaptic polarization
TLDR
By passing polarizing currents through the terminal portion of a motor axon and studying their effects from the other side of the synapse, it was hoped to get further information on the neuromuscular mechanism. Expand
The Croonian Lecture - The transmission of impulses from nerve to muscle, and the subcellular unit of synaptic action
  • B. Katz
  • Biology
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1962
TLDR
This lecture is to show that not only is there a special mechanism of chemical mediation interposed between the two cells, but that the neuromuscular junction possesses the specific synaptic properties which are essential for the integration of converging and conflicting signals in the authors' nerve centres. Expand
Transmission in squid giant synapses: the importance of oxygen supply and the effects of drugs.
TLDR
Intracellular recording with microelectrodes near the synapse showed that the block was associated with a slower rise of the excitatory post-synaptic potential, without a change in the depolarization required to initiate the spike. Expand
Input–Output Relation of a Single Synapse
TLDR
It has been found that brief pulses of depolarization, locally imposed on a motor nerve ending, elicit graded end-plate potentials the size of which can reach or even surpass that normally produced by a nerve impulse. Expand
A quantitative description of membrane current and its application to conduction and excitation in nerve
TLDR
This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms. Expand
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