A study of platelet serotonin receptor in mania.

  title={A study of platelet serotonin receptor in mania.},
  author={Ajay Velayudhan and T. A. Sunitha and Srinivasan Balachander and Janardhana Y C Reddy and Sumant Khanna},
  journal={Biological psychiatry},
  volume={45 8},
BACKGROUND Serotonergic (5-HT) dysfunction has been hypothesized in mania; however platelet studies on the 5-HT uptake rate and the 5-HT transporter have revealed inconsistent results. To the best of our knowledge no studies have been conducted on the 5-HT2 receptor status in mania. METHODS We determined density (Bmax) and dissociation constant (Kd) of 5-HT2 receptors in the platelets of 29 normal control and 29 manic subjects using 125I-ketanserin as the binding radioligand. The manic… CONTINUE READING

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