A study of linkage and association of body mass index in the Old Order Amish.

@article{Platte2003ASO,
  title={A study of linkage and association of body mass index in the Old Order Amish.},
  author={Petra Platte and George J. Papanicolaou and Jason Johnston and Caroline M Klein and Kim Doheny and Elizabeth W. Pugh and M-H Roy-Gagnon and Albert J. Stunkard and Clair A. Francomano and Alexander F. Wilson},
  journal={American journal of medical genetics. Part C, Seminars in medical genetics},
  year={2003},
  volume={121C 1},
  pages={71-80}
}
Obesity is thought to have a genetic component with the estimates of heritability ranging from 0.25-0.40. As part of an ongoing study of obesity in the Old Order Amish, seven two- and three-generation families (157 individuals) were assessed for 21 traits related to obesity, including body mass index (BMI) and BMI-percentile (a standardized distribution of BMI adjusted for age and sex). Genotyping was performed using a panel of 384 short-tandem repeat markers. In this sample, the estimates of… CONTINUE READING

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