[A study of immunocompetence of peptide hormones in human pericardium].

  • Shu Jun Wen
  • Published 1992 in Zhonghua xin xue guan bing za zhi


With RIA/HPLC and immunohistochemistry, the presence of angiotensin(A) and atrial natriuretic factor-like materials (ANF-LMs) was demonstrated in the pericardium of human and rats; the distributions of AII and ANF-LMs were found to be identical; AI was more than AII; renin activity was detected in the pericardium. There were three molecular forms of ANF-LMs in the pericardium. Mesothelial cells were the principal endocrine-secreting cells. AII and ANF-LMs of the pericardium were significantly increased in rheumatic heart disease. There were no correlations between plasma AII, ANF, urine AII, ANF and pericardial AII, ANF (P > 0.05). The data reported showed that the pericardium may have endocrine function under normal and abnormal conditions (heart failure) of the heart, in addition to its known mechanical properties.

Cite this paper

@article{Wen1992ASO, title={[A study of immunocompetence of peptide hormones in human pericardium].}, author={Shu Jun Wen}, journal={Zhonghua xin xue guan bing za zhi}, year={1992}, volume={20 4}, pages={240-2, 260-1} }