Corpus ID: 19205552

A study of hypoglycaemic effects of Azadirachta indica (Neem) in normaland alloxan diabetic rabbits.

@article{Khosla2000ASO,
  title={A study of hypoglycaemic effects of Azadirachta indica (Neem) in normaland alloxan diabetic rabbits.},
  author={P. Khosla and S. Bhanwra and J. Singh and S. Seth and R. Srivastava},
  journal={Indian journal of physiology and pharmacology},
  year={2000},
  volume={44 1},
  pages={
          69-74
        }
}
Key ResultHypoglycaemic effect was observed with Azadirachta indica when given as a leaf extract and seed oil, in normal as well as diabetic rabbits. The effect, however, was more pronounced in diabetic animals in which administration for 4 weeks after alloxan induced diabetes, significantly reduced blood glucose levels. Hypoglycaemic effect was comparable to that of glibenclamide.Expand
Evaluation of Hypoglycemic Activity of Neem (Azadirachta Indica) In Albino Rats
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The influence of single drug and multiple drug effect of the selected drugs on hypoglycaemic activity were studied in Wistar rats. Rats were selected as suitable animal models for the study of theExpand
Antidiabetic effects of Catharanthus roseus , Azadirachta indica , Allium sativum and glimepride in experimentally diabetic induced rat
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The present study clearly indicated the significant antidiabetic activity of Catharanthus Roseus, Azadirachta indica and Allium sativum and supports the traditional usage of the herbal preparations by Ayurvedic physicians for the therapy of diabetics. Expand
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The results of present study revealed the hepatoprotective potential of Azadirachta indica in diabetes by demonstrating less fragmentation, inflammation and decreased tissue level damage after ALE treatment, and corroborated the results of biochemical parameters. Expand
ANTIOXIDANT EFFECT OF ALOE VERA IN EXPERIMENTALLY INDUCED DIABETES MELLITUS
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Treatment with Azadirachta indica in diabetic pregnant rats: negative effects on maternal outcome.
TLDR
Both neem seed oil and azadirachtin impaired intrauterine development and altered antioxidant/oxidative status during pregnancy and increased the proportion of fetuses classified as small for pregnancy age in all groups; and did not interfere with the lipid profile in non-diabetic dams. Expand
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References

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Effects of Azadirachta indica A Juss on some biochemical, immunological and visceral parameters in normal and stressed rats.
TLDR
In stressed rats, AI significantly attenuated the stress-induced suppression of humoral immune response and gastric ulcerogenesis and the possible mechanisms involved in the effects of AI in normal and stressful situations are discussed. Expand
Possible mechanism of antiinflammatory activity of Azadirachta indica leaf extract
TLDR
The result suggests that A.indica extract's antiinflammatory effect may be due to antagonism of the deleterious effect of 5-HT and PGE1 on blood vessels. Expand
A preliminary study on hypoglycaemic and antihyperglycaemic effects of Azadirachta indica
. Aqueous extract of Azadirachta indica was investigated for its effects on blood glucose levels in dogs. It was found to have hypoglycaemic and antihyperglycaemic effects.
Antidermatophytic activity of neem (Azadirachta indica) leaves in Vitro
TLDR
The ethanolic extract was found to be more active inhibiting 90% of the isolates at a concentration of 100 ug/ml while the MIC 50s and MIC 90s of the aqueous extract were 500 and > 500 uG/ml whereas the values for ketoconazole were 1 and 2.5 ug /ml respectively. Expand
Modulation of humoral and cell-mediated immune responses by Azadirachta indica (Neem) in mice.
TLDR
The effects of A. indica (AI, Neem) were evaluated on tests of humoral and cell-mediated immune responses after 3 weeks of oral AI (leaf extract) treatment in ovalbumin immunized mice and there was an enhancement of macrophage migration inhibition, and footpad thickness after AI (100 mg/kg) treatment. Expand
Cholesterol Metabolism in Alloxan-Induced Diabetic Rabbits
TLDR
An increase in intestinal HMG-CoA reductase activity in the poorly controlled diabetic animals occurred in the absence of hyperphagia, and abnormalities in cellular cholesterol metabolism could be partly responsible for the alterations in serum cholesterol levels in diabetes. Expand
Hypoglycaemic activity of Melia azadirachta Linn (Ne em)
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[Enzymatic determination of blood glucose with a modified hexokinase method].
Insulin, oral hypoglycemic agents and the pharmacology of the endocrine pancreas
Hypoglycaemic activity of neem seed oil (Azadirachta indica) on streptozotocin induced diabetic mice
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  • 1990
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