A study of growth hormone release in man after oral administration of amino acids.

@article{Isidori1981ASO,
  title={A study of growth hormone release in man after oral administration of amino acids.},
  author={A. M. Isidori and Andrea Lo Monaco and M. Cappa},
  journal={Current medical research and opinion},
  year={1981},
  volume={7 7},
  pages={
          475-81
        }
}
Key MethodA study was carried out in 15 male volunteers to evaluate qualitatively the secretion of growth factors following stimulation by oral amino acids. The results showed that oral administration of a combination of two amino acids (1200 mg 1-lysine plus 1200 mg 1-arginine) provoked a release of pituitary somatotropin and insulin. This phenomenon was reproducible and the growth hormone secreted in response to this stimulation had biological activity (as demonstrated by a radioreceptor assay and…Expand
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TLDR
Plasma levels of growth hormone have been shown to rise during or following spontaneous and experimentally induced hypoglycemia, prolonged fasting, vigorous muscular exercise, surgical stress, inhibition of glucose utilization by 2-desoxy-glucose, and a rapid and significant fall in blood glucose levels.
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The data shows that arginine is a consistent and potent stimulus for growth hormone release, and is superior to glucagon as a test for growth hormones reserve.
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TLDR
No significant measurement discrepancy was found in basal samples from normal subjects, in contrast to previous findings in acromegalics, and RRA methodology has now been adapted to allow detection of hGH at normal circulating levels.
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Preliminary data indicate increased sensitivity of the prolactin-secreting cells to somatostatin in hypothyroidism and suggest that decreased responsiveness of the somatotrophs to som atostatin could play a role in the pathogenesis of acromegaly.
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