A study of growth hormone release in man after oral administration of amino acids.

@article{Isidori1981ASO,
  title={A study of growth hormone release in man after oral administration of amino acids.},
  author={A. M. Isidori and Andrea Lo Monaco and M. Cappa},
  journal={Current medical research and opinion},
  year={1981},
  volume={7 7},
  pages={
          475-81
        }
}
Key MethodA study was carried out in 15 male volunteers to evaluate qualitatively the secretion of growth factors following stimulation by oral amino acids. The results showed that oral administration of a combination of two amino acids (1200 mg 1-lysine plus 1200 mg 1-arginine) provoked a release of pituitary somatotropin and insulin. This phenomenon was reproducible and the growth hormone secreted in response to this stimulation had biological activity (as demonstrated by a radioreceptor assay and…Expand
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Growth hormone responses to varying doses of oral arginine.
  • S. Collier, Darren P. Casey, J. Kanaley
  • Biology, Medicine
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2005
TLDR
A 13 g dose of arginine resulted in considerable gastrointestinal distress in most subjects without augmentation in the GH response and the rise in GH concentration started approximately 30 min after ingestion and peaked approximately 60 min post ingestion.
Effects of oral ingestion of amino acids and proteins on the somatotropic axis.
TLDR
Ingestion of soy protein, either hydrolyzed or intact, as well as AAs reflecting soyprotein, stimulates GH release to a similar extent.
Low-dose amino acid supplementation: no effects on serum human growth hormone and insulin in male weightlifters.
TLDR
The ergogenic value of low-dose oral amino acid supplementation in increasing hGH or insulin secretion seems questionable.
Effect of Amino Acids on Growth Hormone Release.
  • B. Jacobson
  • Chemistry, Medicine
    The Physician and sportsmedicine
  • 1990
TLDR
It is possible that growth-hormone-induced muscle hypertrophy lacks corresponding strength properties because of increases in noncontractile protein, and additional research is needed to determine what effect, if any, combining amino acid supplementation with weight training has on muscle strength andhypertrophy.
Acute amino acids supplementation enhances pituitary responsiveness in athletes.
TLDR
The amino acid mixture used enhanced the ACTH, LH, and FSH response to CRH + GnRH and significantly higher in AS group both as absolute values and area under curve (AUC) values than in P1-AS group.
A Pilot Study in Normal Volunteers of the Effects of the Renuva™ System on Growth Hormone and Insulin-Dependent Growth Factor-1
TLDR
The Renuva™ System increases GH and IGF-1 and both the Generator Drink and the Infuser Spray appear to contribute to the increase in IGF- 1.
Recovery of low thymic hormone levels in cancer patients by lysine-arginine combination.
Neuroendocrine control of growth hormone secretion.
The secretion of growth hormone (GH) is regulated through a complex neuroendocrine control system, especially by the functional interplay of two hypothalamic hypophysiotropic hormones, GH-releasing…
Increased Human Growth Hormone After Oral Consumption of an Amino Acid Supplement: Results of a Randomized, Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects.
TLDR
Results show that a single dose of the oral amino acid supplement was sufficient to significantly increase hGH levels in healthy adult men and women.
Growth hormone, arginine and exercise
  • J. Kanaley
  • Medicine
    Current opinion in clinical nutrition and metabolic care
  • 2008
TLDR
At rest oral L-arginine ingestion will enhance the growth hormone response and the combination of arginine plus exercise increases growth hormone, but this increase may be less than seen with exercise alone.
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References

SHOWING 1-10 OF 10 REFERENCES
PLASMA GROWTH HORMONE RESPONSE TO INTRAVENOUS ADMINISTRATION OF AMINO ACIDS.
TLDR
Plasma levels of growth hormone have been shown to rise during or following spontaneous and experimentally induced hypoglycemia, prolonged fasting, vigorous muscular exercise, surgical stress, inhibition of glucose utilization by 2-desoxy-glucose, and a rapid and significant fall in blood glucose levels.
Assessment of growth hormone reserve: comparison of intravenous arginina and subcutaneous glucagon stimulation tests.
TLDR
The data shows that arginine is a consistent and potent stimulus for growth hormone release, and is superior to glucagon as a test for growth hormones reserve.
A simple oral test of growth-hormone secretion in children.
Sequential study of arginine monochloride and normal saline as stimuli to growth hormone release.
Radioreceptor-inactive growth hormone associated with stimulated secretion in normal subjects.
TLDR
No significant measurement discrepancy was found in basal samples from normal subjects, in contrast to previous findings in acromegalics, and RRA methodology has now been adapted to allow detection of hGH at normal circulating levels.
Effect of somatostatin on thyrotropin, prolactin, growth hormone and insulin responses to thyrotropin releasing hormone and arginine in healthy, hypothyroid and acromegalic subjects.
TLDR
Preliminary data indicate increased sensitivity of the prolactin-secreting cells to somatostatin in hypothyroidism and suggest that decreased responsiveness of the somatotrophs to som atostatin could play a role in the pathogenesis of acromegaly.
Determination of the optimum dietary proportions of lysine and tryptophan for growing rats based on growth, food intake and plasma metabolites.
TLDR
The optimum lysine:tryptophan ratio was between 4 and 5 for the rapidly growing 3- to 6-week old rat, and a tryptophan requirement of approximately 0.15% whenLysine was adequate.
Comparative effects of glucagon and arginine upon growth hormone secretion in children and adolescents.
BESOINS DU PINTADEAU DE CHAIR EN LYSINE ET EN ACIDES AMINÉS SOUFRÉS PENDANT LES PÉRIODES DE CROISSANCE ET DE FINITION
Effect of arginine on serum-levels of human growth-hormone.