A study of genetic (CYP2D6 and ABCB1) and environmental (drug inhibitors and inducers) variables that may influence plasma risperidone levels.

@article{Leon2007ASO,
  title={A study of genetic (CYP2D6 and ABCB1) and environmental (drug inhibitors and inducers) variables that may influence plasma risperidone levels.},
  author={Joshua De Leon and Margaret T. Susce and R-M Pan and Peter J. Wedlund and Mario Orrego and Francisco J D{\'i}az},
  journal={Pharmacopsychiatry},
  year={2007},
  volume={40 3},
  pages={93-102}
}
Risperidone (R) is metabolized to 9-hydroxyrisperidone (9-OHR) by cytochrome P450 2D6 (CYP2D6). The main objective of this naturalistic study was to investigate the variables associated with two plasma ratios: the plasma R:9-OHR concentration ratio and the total concentration-to-dose (C:D) ratio. These ratios were studied as continuous measures by linear regression analyses and as three dichotomous variables in logistic regression analyses: R:9-OHR ratio >1 (indicative of lack of CYP2D6… CONTINUE READING

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