A study of fucoidan from the brown seaweed Chorda filum.

@article{Chizhov1999ASO,
  title={A study of fucoidan from the brown seaweed Chorda filum.},
  author={Alexander O Chizhov and Anne Dell and Howard R. Morris and Stuart M. Haslam and Roy A. McDowell and Alexander S. Shashkov and Nikolay E. Nifant'ev and Elena A. Khatuntseva and Anatolii I. Usov},
  journal={Carbohydrate research},
  year={1999},
  volume={320 1-2},
  pages={
          108-19
        }
}
Fucoidan fractions from the brown seaweed Chorda filum were studied using solvolytic desulfation. Methylation analysis and NMR spectroscopy were applied for native and desulfated polysaccharides. Homofucan sulfate from C. filum was shown to contain poly-alpha-(1-->3)-fucopyranoside backbone with a high degree of branching, mainly of alpha-(1-->2)-linked single units. Some fucopyranose residues are sulfated at O-4 (mainly) and O-2 positions. Some alpha-(1-->3)-linked fucose residues were shown… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Structural characterization of a new anticoagulant fucan sulfate from the brown seaweed Ecklonia kurome.
TLDR
Results suggested a highly branched, new type of fucan sulfate containing a backbone of (1----3)-linked L-fucosyl residues having sulfate groups mainly attached to C-4. Expand
An anticoagulant fucoidan from the brown seaweed Ecklonia kurome.
The structure of a alpha-L-fucose-rich, sulphated polysaccharide (C-I) with a potent anticoagulant activity, which was isolated from the brown seaweed Ecklonia kurome, has been studied. MethylationExpand
New data on the structure of laminaran fromChorda filum (L.) Lam. and reserve glucans from other brown algae
M-chains of highly branched (1→3),(1→6)-β-D-glucan (laminaran) isolated previously from the brown algaChorda filum contain 1-glucosylated and 1,6-bis-glucosylatedD-mannitol residues, as shown byExpand
Sulfated fucans from echinoderms have a regular tetrasaccharide repeating unit defined by specific patterns of sulfation at the 0-2 and 0-4 positions.
TLDR
NMR spectroscopy indicates that both polysaccharides have a tetrasaccharide repeat unit in which the separate residues differ only in the extent and position of their sulfate substitution. Expand
A revised structure for fucoidan may explain some of its biological activities.
TLDR
The revised average structure for fucoidan is consistent with previous studies suggesting a branched random coil as the best model for this polysaccharide and the proposed model is a closer structural analogue of the sulfated carbohydrate ligands that bind to selectins. Expand
Antitumor activity and immunological properties of marine algal polysaccharides, especially fucoidan, prepared from Sargassum thunbergii of Phaeophyceae.
TLDR
The results of carbon clearance activity with fucoidan demonstrated that it is acting as a so-called activator of the reticuloendothelial system as well as the enhancement of immune responses. Expand
Computer-assisted analysis of the structure of regular branched polysaccharides containing 2,3-disubstituted rhamnopyranose and mannopyranose residues on the basis of 13C NMR data.
A computer-assisted approach to the analysis of the structure of branched polysaccharides that contain 2,3-di-O-glycosylated alpha-rhamnopyranose and alpha-mannopyranose residues is based onExpand
Structural analysis of laminarans by MALDI and FAB mass spectrometry
Abstract MALDI and FAB mass spectrometry were applied to eight samples of laminarans from different algal species. The existence of both M-chains (mannitol-containing) and G-chains (mannitol-free)Expand
Application of two new methods for cleavage of polysaccharides into specific oligosaccharide fragments. Structure of the capsular and extracellular polysaccharides of Rhizobium japonicum that bind soybean lectin.
TLDR
From the composition and the structural analyses of the tetra- and trisaccharides produced in high yields by specific degradations of the polysaccharide, the polymer is deduced to have a pentasaccharide repeating unit with Structure 3: (formula: see text). Expand
Determination, by methylation analysis, of the glycosyl-linkage compositions of microgram quantities of complex carbohydrates
Abstract A methylation-analysis procedure has been developed by which the glycosyl-linkage compositions of microgram quantities of complex carbohydrates, including those containing hexosyluronic acidExpand
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