A study of drug action on normal and denervated striatal mechanisms.

@article{Costall1979ASO,
  title={A study of drug action on normal and denervated striatal mechanisms.},
  author={Brenda Costall and D. H. Fortune and Robert J. Naylor and Virinder Nohria},
  journal={European journal of pharmacology},
  year={1979},
  volume={56 3},
  pages={
          207-16
        }
}
Abstract Apomorphine, N-n-propylnorapomorphine, N,N-di-n-propyldopamine, 1-aza-7,8-dihydroxy-1-a-1,2,3,4,4a,9, 10,10a-octahydrophenanthrene (CS-224) and 2-di-n-propylamino-5,6-dihydroxytetralin each caused ipsilateral circling (with respect to the side of electrolesion) in mice with electrolesions of the striatum or electrolesions combined with 6-hydroxydopamine (6-OHDA) lesions of the contralateral straitum. All agents were more potent (2–4 fold) in the latter model: the shift of the dose… 
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TLDR
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Unilateral striatal dopamine denervation: Reduced motor inhibitory effects of dopamine antagonists revealed in models of asymmetric and circling behaviour
TLDR
Selective striatal denervation techniques are used to show that asymmetric and circling behaviours can be differentially induced and manipulated, and that the increased sensitivity (over electrolesions) of 6-OHDA lesioned rats to dopamine agonist action to induce these behavioural effects is associated with a reduced sensitivity to neuroleptic activity to reduce the asymmetry and circling responses.
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