A study of common discovery dosing formulation components and their potential for causing time-dependent matrix effects in high-performance liquid chromatography tandem mass spectrometry assays.

@article{Xu2005ASO,
  title={A study of common discovery dosing formulation components and their potential for causing time-dependent matrix effects in high-performance liquid chromatography tandem mass spectrometry assays.},
  author={Xiaoying Xu and Hong Mei and Shiyong Wang and Qiao Zhou and Ganfeng Wang and Lisa Broske and Adrienne Pena and Walter A. Korfmacher},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2005},
  volume={19 18},
  pages={2643-50}
}
Hydroxyproyl-beta-cyclodextran (HPBCD), methyl cellulose (MC), Tween 80 and PEG400 are commonly used in dosing formulations in pharmacokinetic (PK) studies during the early drug discovery stage. A series of studies was designed to evaluate the potential matrix effects of these dosing vehicles when the samples are assayed by high-performance liquid chromatography combined with tandem mass spectrometry (HPLC/MS/MS). These dosing vehicles were dosed into the rats via either an intravenous (IV) or… CONTINUE READING

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