A study of P2X1 receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors.

@article{Vial2002ASO,
  title={A study of P2X1 receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors.},
  author={Catherine Vial and Michael G Rolf and Martyn P. Mahaut-Smith and Richard J. Evans},
  journal={British journal of pharmacology},
  year={2002},
  volume={135 2},
  pages={363-72}
}
We have examined the role of ATP-dependent P2X(1) receptors in megakaryocytes (MKs) and platelets using receptor-deficient mice and selective agonists. Alpha,beta-meATP- and ATP- evoked ionotropic inward currents were absent in whole-cell recordings from MKs of P2X(1)(-/-) mice, demonstrating that the P2X receptor phenotype in MKs, and by inference… CONTINUE READING