A study of Italian pediatric celiac disease patients confirms that the primary HLA association is to the DQ(alpha 1*0501, beta 1*0201) heterodimer.

@article{Mazzilli1992ASO,
  title={A study of Italian pediatric celiac disease patients confirms that the primary HLA association is to the DQ(alpha 1*0501, beta 1*0201) heterodimer.},
  author={Maria Cristina Mazzilli and Pasquale Ferrante and Paolo Mariani and Enrico Martone and Fiorella Petronzelli and P. Triglione and Margherita Bonamico},
  journal={Human immunology},
  year={1992},
  volume={33 2},
  pages={133-9}
}
Celiac disease (CD) has been recently reported to be primarily associated with the DQ(alpha 1*0501, beta 1*0201) heterodimer encoded in cis on DR3 haplotype and in trans in DR5,7 heterozygous individuals. The high incidence of DR5,7 heterozygotes, reflecting the high frequency of the DR5 allele in Italy, makes the analysis of the Italian CD patients critical. Polymerase chain reaction-amplified DNA from 50 CD patients and 50 controls, serologically typed for DR and DQw antigens, was hybridized… CONTINUE READING

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