A study of French centenarians: are ACE and APOE associated with longevity?

@article{Blanch2001ASO,
  title={A study of French centenarians: are ACE and APOE associated with longevity?},
  author={H{\'e}l{\`e}ne Blanch{\'e} and Ludovic Cabanne and Mourad Sahbatou and Gilles Thomas},
  journal={Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie},
  year={2001},
  volume={324 2},
  pages={129-35}
}
Association study is the method of choice to identify genes involved in complex processes that result from the interaction of environmental and genetic factors. However, because of biases that increase the risk of false positive reports, preliminary positive conclusions have to be reproduced on other populations to be validated as firm conclusions. In 1994, certain alleles of two genes, APOE (Apolipoprotein E) and ACE (angiotensin converting enzyme), were reported to be more frequent in French… CONTINUE READING

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