A study of CD33 (SIGLEC‐3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing

@article{HernndezCaselles2006ASO,
  title={A study of CD33 (SIGLEC‐3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing},
  author={Trinidad Hern{\'a}ndez-Caselles and Mar{\'i}a Mart{\'i}nez-Esparza and Ana B. P{\'e}rez-Oliva and Ana M. Quintanilla‐Cecconi and Ana Mar{\'i}a Garc{\'i}a-Alonso and D. Mar{\'i}a Roc{\'i}o Alvarez‐L{\'o}pez and Pilar Garc{\'i}a-Pe{\~n}arrubia},
  journal={Journal of Leukocyte Biology},
  year={2006},
  volume={79}
}
The expression of CD33, a restricted leukocyte antigen considered specific for myeloid lineage, has been studied extensively on lymphoid cells. We demonstrated that wide subsets of mitogen‐ or alloantigen‐activated human T and natural killer (NK) cells express CD33 at protein and nucleic acid levels. CD33+ and CD33– T and NK cell populations showed identical surface expression of activation markers such as CD25, CD28, CD38, CD45RO, or CD95. Myeloid and lymphoid CD33 cDNA were identical. However… 
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