A study in contrasts: eligibility criteria in a twenty-year sample of NSABP and POG clinical trials. National Surgical Adjuvant Breast and Bowel Program. Pediatric Oncology Group.

@article{Fuks1998ASI,
  title={A study in contrasts: eligibility criteria in a twenty-year sample of NSABP and POG clinical trials. National Surgical Adjuvant Breast and Bowel Program. Pediatric Oncology Group.},
  author={Abraham Fuks and Charles Weijer and Benjamin Freedman and Stan Shapiro and M Skrutkowska and Ahsun Riaz},
  journal={Journal of clinical epidemiology},
  year={1998},
  volume={51 2},
  pages={69-79}
}
We studied changes in eligibility criteria--the largest impediment to patient accrual--in two samples of clinical trials. Trials from the NSABP (National Surgical Adjuvant Breast and Bowel Program) and POG (Pediatric Oncology Group) were analyzed. After eliminating duplications, the criteria in each protocol were enumerated and classified according to a novel schema. NSABP trials contained significantly more criteria than POG trials, and added precision criteria (making study populations… CONTINUE READING