A structure-function study of PACAP using conformationally restricted analogs: Identification of PAC1 receptor-selective PACAP agonists.

@article{Ramoslvarez2015ASS,
  title={A structure-function study of PACAP using conformationally restricted analogs: Identification of PAC1 receptor-selective PACAP agonists.},
  author={Irene Ramos-{\'A}lvarez and Samuel A. Mantey and Taichi Nakamura and Bernardo Nuche-Berenguer and Paola Sanchez Moreno and Terry W. Moody and Jerome L. Maderdrut and D. H. Coy. E. J. Coy and Robert Thomas Jensen},
  journal={Peptides},
  year={2015},
  volume={66},
  pages={26-42}
}
Pituitary adenylate cyclase-activating polypeptide (PACAP) has widespread physiological/pathophysiological actions and there is increased interest for its use therapeutically, especially in the CNS (neuroprotection). Unfortunately, no selective PACAP-analogs exist for PACAP-preferring PAC1-receptors, primarily because of its high sequence identity to VIP and particularly, because of the inability of structure-function studies to separate the pharmacophore of PAC1-R from VPAC1-R, which has high… CONTINUE READING

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