A structure-based model of substrate discrimination by a noncanonical PDZ tandem in the intramembrane-cleaving protease RseP.

@article{Hizukuri2014ASM,
  title={A structure-based model of substrate discrimination by a noncanonical PDZ tandem in the intramembrane-cleaving protease RseP.},
  author={Yohei Hizukuri and Takashi Oda and Sanae Tabata and Keiko Tamura-Kawakami and Rika Oi and Mamoru Sato and Junichi Takagi and Yoshinori Akiyama and Terukazu Nogi},
  journal={Structure},
  year={2014},
  volume={22 2},
  pages={326-36}
}
During the extracytoplasmic stress response in Escherichia coli, the intramembrane protease RseP cleaves the anti-σ(E) protein RseA only after the membrane-anchored protease DegS truncates the periplasmic part of RseA that suppresses the action of RseP. Here we analyzed the three-dimensional structure of the two tandemly arranged PSD-95/Dlg/ZO-1 (PDZ) domains (PDZ tandem) present in the periplasmic region of RseP and revealed that the two putative ligand-binding grooves constitute a single… CONTINUE READING
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