A structure-based model for ligand binding and dimerization of EGF receptors.

@article{Klein2004ASM,
  title={A structure-based model for ligand binding and dimerization of EGF receptors.},
  author={Peter G. Klein and Dawn R Mattoon and Mark A Lemmon and Joseph Schlessinger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 4},
  pages={929-34}
}
On the basis of the 3D structures of the extracellular ligand-binding domains of the epidermal growth factor (EGF) receptor (EGFR) and ErbB3, a mechanism has been proposed for how the extracellular region of the EGFR is maintained in an autoinhibited configuration and for how EGF binding induces EGFR dimerization and activation. We have attempted to derive a mathematical model for EGF binding to the EGFR and for ligand-induced receptor dimerization and activation that uses this structural… CONTINUE READING

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