A structure-based approach to a synthetic vaccine for HIV-1.

@article{Cabezas2000ASA,
  title={A structure-based approach to a synthetic vaccine for HIV-1.},
  author={Edelmira Cabezas and Mengmeng Wang and Paul W H I Parren and Robyn L Stanfield and Arnold C. Satterthwait},
  journal={Biochemistry},
  year={2000},
  volume={39 47},
  pages={14377-91}
}
The generation of neutralizing antibodies by peptide immunization is dependent on achieving conformational compatibility between antibodies and native protein. Consequently, approaches are needed for developing conformational mimics of protein neutralization sites. We replace putative main-chain hydrogen bonds (NH --> O=CRNH) with a hydrazone link (N-N=CH-CH(2)CH(2)) and scan constrained peptides for fit with neutralizing monoclonal antibodies (MAbs). To explore this approach, a V3 MAb 58.2… CONTINUE READING