A structure-based approach for prediction of MHC-binding peptides.

  title={A structure-based approach for prediction of MHC-binding peptides.},
  author={Yael Altuvia and Hanah Margalit},
  volume={34 4},
Identification of immunodominant peptides is the first step in the rational design of peptide vaccines aimed at T-cell immunity. The advances in sequencing techniques and the accumulation of many protein sequences without the purified protein challenge the development of computer algorithms to identify dominant T-cell epitopes based on sequence data alone. Here, we focus on antigenic peptides recognized by cytotoxic T cells. The selection of T-cell epitopes along a protein sequence is… CONTINUE READING

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