A structure-activity study to identify novel and efficient substrates of the human semicarbazide-sensitive amine oxidase/VAP-1 enzyme.

@article{Bonaiuto2010ASS,
  title={A structure-activity study to identify novel and efficient substrates of the human semicarbazide-sensitive amine oxidase/VAP-1 enzyme.},
  author={Emanuela Bonaiuto and Michele Lunelli and Marina Scarpa and Roberto Vettor and Gabriella Milan and Maria Luisa di Paolo},
  journal={Biochimie},
  year={2010},
  volume={92 7},
  pages={858-68}
}
Kinetic studies were performed with various alkanamines as "substrate probes" of the properties of the active site of the human semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1). We found that the enzyme-substrate recognition step is mainly controlled by apolar interactions and that a "good" substrate has a molecular structure containing a long aliphatic chain and a second positive charge at a distance greater than 12 A from the reactive amino group. In this context… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Structure and inhibition of human diamine oxidase.

Biochemistry • 2009
View 10 Excerpts
Highly Influenced

J

F. Yraola, S. Garcia-Vicente
Fernandez-Recio, et al., New efficient substrates for semicarbazide-sensitive amine oxidase/VAP-1 enzyme: analysis by SARs and omputaional docking. J. Med. Chem. 49 • 2006
View 7 Excerpts
Highly Influenced

D

P. Dunkel, A. Gelain
Barlocco, et al., Semicarbazide-sensitive amine oxidase/ vascular adhesion protein-1: recent developments concerning substrates and inhibitors of a promising therapeutic target. Curr. Med. Chem. 15 • 2008

VAP-1 and CD73

S. Jalkanen, M. Salmi
endothelial cell surface enzymes in leukocyte extravasation. Arterioscler Thromb. Vasc. Biol. 28 • 2008
View 1 Excerpt

L

S. Garcia-Vicente, F. Yraola
Marti, et al., Oral insulin-mimetic compounds that act independently of insulin. Diabetes 56 • 2007
View 2 Excerpts

Similar Papers

Loading similar papers…