A structurally biased combinatorial approach for discovering new anti-picornaviral compounds.

Abstract

BACKGROUND Picornaviruses comprise a family of small, non-enveloped RNA viruses. A common feature amongst many picornaviruses is a hydrophobic pocket in the core of VP1, one of the viral capsid proteins. The pocket is normally occupied by a mixture of unidentified, fatty acid-like moieties, which can be competed out by a family of capsid-binding, antiviral… (More)

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Cite this paper

@article{Tsang2001ASB, title={A structurally biased combinatorial approach for discovering new anti-picornaviral compounds.}, author={S K Tsang and Jigger Cheh and Lyle D Isaacs and Diane Joseph-McCarthy and Sylvia K. Choi and Daniel C. Pevear and George M. Whitesides and James M. Hogle}, journal={Chemistry & biology}, year={2001}, volume={8 1}, pages={33-45} }