A structurally abnormal insulin causing human diabetes

@article{Tager1979ASA,
  title={A structurally abnormal insulin causing human diabetes},
  author={Howard S. Tager and Barbara A. Given and Donald R. Baldwin and Mary E. Mako and J Markese and A. Rubenstein and Jerrold Olefsky and Mieko Kobayashi and Orville Kolterman and R L Poucher},
  journal={Nature},
  year={1979},
  volume={281},
  pages={122-125}
}
Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studies suggest that the isolated hormone is a mixture of normal insulin and an abnormal variant which contains a leucine for phenylalanine substitution at position 24 or 25 of the insulin B-chain. 

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