A structural superfamily of growth factors containing a cystine knot motif

@article{McDonald1993ASS,
  title={A structural superfamily of growth factors containing a cystine knot motif},
  author={Neil Q. McDonald and Wayne A. Hendrickson},
  journal={Cell},
  year={1993},
  volume={73},
  pages={421-424}
}

Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules.

TLDR
They are absent in the unicellular yeast genome but present in nematode, fly, and higher species, indicating that the cystine knot structure evolved in extracellular signaling molecules of multicellular organisms.

Molecular architecture and biorecognition processes of the cystine knot protein superfamily: part I. The glycoprotein hormones

TLDR
This review article focuses on the structural motifs involved in receptor recognition and the current techniques available to identify these regions, including the role of immunological methodology, peptide fragment design and synthesis and mutagenesis to delineate their structure–function relationships and molecular recognition behaviour.

The cystine knot structure of ion channel toxins and related polypeptides.

Oxidative folding of cyclic cystine knot proteins.

TLDR
The points summarized in this review will be important to consider in the design of novel pharmaceutically interesting biomolecules based on the cyclic cystine knot motif, which has shown potential as a molecular scaffold because of its exceptional stability.

Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity.

TLDR
The three-dimensional solution structure of circulin A, a 30 residue polypeptide from the African plant Chassalia parvifolia, has been determined using two-dimensional 1H-NMR spectroscopy and provides additional evidence for a solvent-exposed Trp residue.

Molecular modelling of the Norrie disease protein predicts a cystine knot growth factor tertiary structure

TLDR
This model identifies Norrie disease protein (NDP) as a member of an emerging family of growth factors containing a cystine knot motif, with direct implications for the physiological role of NDP.

Acyclic Permutants of Naturally Occurring Cyclic Proteins

TLDR
The complete suite of acyclic permutants of kalata B1 are synthesized and it is shown that it is possible to disrupt regions of the β-sheet and still allow folding into native-like structure, provided the cystine knot is intact.

Diversity in the disulfide folding pathways of cystine knot peptides

TLDR
This work has examined the oxidative refolding and reductive unfolding of the prototypic member of the cyclotide family, kalata B1, suggesting that the circular backbone has a significant influence in directing the folding pathway.

The cystine knot motif in toxins and implications for drug design.

  • D. CraikN. DalyC. Waine
  • Biology, Chemistry
    Toxicon : official journal of the International Society on Toxinology
  • 2001
...

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