A structural step into the SRP cycle.

  title={A structural step into the SRP cycle.},
  author={Klemens Wild and Ken Roger Rosendal and Irmgard Sinning},
  journal={Molecular microbiology},
  volume={53 2},
Co-translational targeting of secretory and membrane proteins to the translocation machinery is mediated by the signal recognition particle (SRP) and its membrane-bound receptor (SR) in all three domains of life. Although the overall composition of the SRP system differs, the central ribonucleoprotein core and the general mechanism of GTP-dependent targeting are highly conserved. Recently, structural studies have contributed significantly to our understanding of the molecular organization of… CONTINUE READING
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