A structural scaffolding of intermediate filaments in health and disease.

@article{Fuchs1998ASS,
  title={A structural scaffolding of intermediate filaments in health and disease.},
  author={Elaine Fuchs and Don W Cleveland},
  journal={Science},
  year={1998},
  volume={279 5350},
  pages={
          514-9
        }
}
The cytoplasm of animal cells is structured by a scaffolding composed of actin microfilaments, microtubules, and intermediate filaments. Intermediate filaments, so named because their 10-nanometer diameter is intermediate between that of microfilaments (6 nanometers) and microtubules (23 nanometers), assemble into an anastomosed network within the cytoplasm. In combination with a recently identified class of cross-linking proteins that mediate interactions between intermediate filaments and the… CONTINUE READING
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